I’m a pro user with over two decades of experience, I don’t use Gnome all the time (I prefer Sway these days), but I’m all-in for having a nice DE that would embrace regular people with its simplicity. IMO Gnome does that very well. Yet, I am, as a pro-user can use that almost as good as I use my sway desktop. At home, our shared guest room computer runs default Fedora, and I don’t feel any limitations with it (it has almost none of my configs), and can do most of my work when I’m up to it. The only real difference is when I want to spend like a whole day working with it. An hour or two, no real difference.
Saying that, why won’t you just use the DE targeted at you, as a pro user? With Gnome, I rather afraid they might mess the simplicity at some point and start doing features features features for the sake of them. See KDE Plasma with their settings. I used it since KDE2, and while I rather like it, I am still getting lost in all the bells and whistles. They are too many, and I’ve been around for a really long time.