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Comment by clickety_clack | Hacker News Reader

I know we can tell that a chemical does a particular thing in the body, but can we tell that it does not do anything other than that thing? The body is ridiculously complex, and as far as I know we don’t know how every part (or combination of parts) works.

Edit: I mean in the theoretical “this targets the x receptor” kind of way, not in “we tested this and found no causal link” way.

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That's why I'm genuinely asking why this would be disappointing, like what was the evidence that this does affect Alzheimer's. You would expect by X does not affect Y by default, so clearly there had to be a theory why you'd spend 2 years on a study to rule it out.

Ozempic is a diabetes drug, and there's a hypothesis that Alzheimer's is really a form of diabetes.

Personally, living with two T1D ( type 1 insulin dependent diabetic, the autoimmune disease not to be confused with the i am old, fat and over eat disorder) when your blood sugar is too high or low , you act weird , you are in a fog . Long term effects of the swings and sustained levels cause brain damage, not necessarily traumatic brain injuries but damage nonetheless.

So i can see the correlation for T1D and undiagnosed T2D cases Alzheimers. Now having a parent with both T2D and Alzheimers when they were taking rebelsis there was a change in their overall mood and activity , but i saw the change was "hey your sugar is under control, and no i am not your buddy from the army" . To be clear the difference is the fog of being unclear about what's going on like you're drunk , vs the grand delusions of seeing a different person that's not there .

This should have been obvious for the researchers.

> This should have been obvious for the researchers.

That's why they do research, to find out instead of just guessing.

T2D is not limited to "old, fat overeaters".

Significant, sustained weight loss can prevent or reduce the effects of conditions known to increase the likelihood or hasten the onset of Alzheimer's, like diabetes and high blood pressure.

This is anecdotal, I don't have proof but it's something I think is somewhat related. Is that obesity and nuerodegenerative diseases are somewhat related. So that's a guess as to why some people might have though a weight loss drug would potentially be related in some way with alzheimers.

This could just be false though, I can't recall where I heard this information. So do some searching before quoting me.

Obesity often goes hand in hand with poorly regulated blood sugar and high blood pressure, both known risk factors for Alzheimer's.

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