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Comment by Trasmatta | Hacker News Reader

But also be careful about taking too much choline. There's lots of anecdotal reports of people taking too much choline supplements and becoming massively depressed.

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The other problem with supplementing with too much choline may be elevated TMAO:

"Dietary Choline Supplements, but Not Eggs, Raise Fasting TMAO Levels in Participants with Normal Renal Function: A Randomized Clinical Trial"

https://pmc.ncbi.nlm.nih.gov/articles/PMC8410632/

It helps to mention what TMAO is:

> Choline is a dietary precursor to the gut microbial generation of the pro-thrombotic and pro-atherogenic metabolite trimethylamine-N-oxide (TMAO).

Helped a little?

My takeaway: do please go ahead and add egg to your diet.

Big Egg paid you to say this, didn't they?

I do prefer a Big Egg.

Brown ones, too.

I haven’t looked, but I bet that tracks with nutritional value.

There's no nutritional difference between brown and white eggs

Exactly something that the white egg-faction of Big Egg cartel would pay you to say.

Dagnammit - they're onto us and our misinformation campaign.

Best get back to just painting them brown.

But brown does usually mean "biggest egg you're going to get here"!

Yep brown eggs are laid by brown/red coloured breeds which do tend to be larger than white hens. They have the same nutritional profile though.

It seems that the active form of choline, phosphatidylcholine, also did not increase TMAO levels.

Interestingly many antidepressants are anticholinergic (as are many nootropes, so you have to be super careful mixing to the two).

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