Being a decade deep into a tightened border blockade that leaves little hope of a long-term future for Gaza.
Netanyahu's coalition getting more and more aggressive with their rhetoric as far as forcibly annexing what remains of the West Bank, rather than merely annexing small portions every year to house more and more settlers. Repeated open provocations at the Al Aqsa Mosque holy site whenever Netanyahu was feeling politically vulnerable.
The US first unilaterally tearing up a treaty to reimpose crippling sanctions, and later inviting the #2 or #3 (depending on how you count) top-ranked leader of Iran, by far the most popular person in the country, to peace talks and then assassinating him when his plane landed.
The imminent threat of the Abraham Accords, Israel and the US trying to bribe leaders of regional governments into a coalition against Iran and Palestine.