Technically speaking, you can run anything on anything since stuff Turing complete. Practically speaking however....

E.g. i have half of macos games in my steam library as a 32-bit mac binaries. I don't know a way to launch them at any reasonable speed. Best way to do it is to ditch macos version altogether and emulate win32 version of the game (witch will run at reasonable speed via wine forks). Somehow Win32 api is THE most stable ABI layer for linux & mac