1. it doesn't (at least recently?) always do a great job of handling multiple displays, either launching games on my second monitor, which I orient vertically or getting confused about which monitor to use and switching back and forth until eventually the instance (but not the Lutris client) crashes
2. I find myself getting into launcher hell where I'll use a different wine version for one game and when I switch to a different game, it's using this new wine version and stops working
Not sure if Heroic solves these issues but I would try it again (didn't have any luck setting it up initially) if it does