In some sense, our small size with respect to astronomical-scale processes does not make us all that fragile, because we are also very short-lived with respect to these things.

Afraid of the impending collision of Andromeda with the Milky Way? Not to worry. Life as we know will be gone by then. Huge processes like galactic mergers are "in slow motion" relative to our every day processes due to light speed bounds. The time they take to occur is enormous because the distances involved are enormous. In a cool way, the presence and influence of an astronomical object is just as insignificant to our processes as the presence and influence of one electron, and for the same reason: enormous difference of scale. The big stuff is no more scary than the small stuff.