Alcohol - stopped having an intoxicating effect on me. I feel a change in my balance and reaction time but there is almost no buzz or no buzz sometimes. alcohol used to always give me a buzz, feel silly, relaxed etc. if you look on pubmed there is some published research that notes this in their results. and if look online you can find personal accounts.

now it makes me feel a little anxious. it also gives me silent reflux feeling, which that i think already was there before as ive gotten older.

in short - before trying alcohol always made feel the same way - since trying that drug ive literally never felt that way from alcohol ever again. i never was much of a drinker only in college and a few years after. but even if you have wine at a guests house at dinner you can feel its effects quickly. thats just been completely gone ever since.

otherwise see my other comment https://news.ycombinator.com/item?id=45502828