If you mean "can it be done with the connections" the answer is yes, as there are many PCIe x4 add-inboards for an external oculink port on the market.

As for framework's desktop specifically, their site says this about the PCIe x4 slot:

>1 x PCIe x4 slot (not exposed on default case)

No opening in the back of the case for an expansion card that exposes ports. My guess is you would be best off putting the mainboard in a different case, but alternatively you could either:

(A) Cut a big hole in the back that can expose an AIB with an external oculink.

(B) Use an internal oculink, and cut a smaller hole (anywhere you want) to run the oculink cable through.

You mean like fish a cable through the case? It looks like it might be doable based on the pictures. If its in the right spot, you might even be able to 3D print a cable gland or something at the case. Hard to tell based on the pictures.

oculink is basically just pcie, you can get a dumb adapter card for like $20

There a cables/adapters to use NVMe slot for oculink. It should "just work".