Regret is different than doing something that didn't turn out well. I have made plenty of decisions that caused a great deal of suffering - but they made me who I am. I think what I would regret would be if I made decisions that didn't make me into a better, more interesting person. Better to have loved and lost, and all that. I guess that whether regret-minimization is a useful framework depends on how precisely we define regret. I am risk-seeking, I fall down a lot, but I never regret anything.