The difference shows up when you perform - perform with Suno on stage and then with Guitar, you will know then.
Where playing an instrument means balancing the handling of tempo, rhythm and notes while mastering your human limitations, a tool like SuperCollider lets you just define these bits as reactive variables. The focus in SuperCollider is on audio synthesis and algorithmic composition, that's closer to dynamically stringing a guitar in unique rule-based ways - mastering that means bridging music- and signal-processing theories while balancing your processing resources. Random generators in audio synthesis are mostly used to bring in some human depth to it.