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Comment by sys32768 | Hacker News Reader

For the non-partisans who actually care more about autism in children than they do throwing ideological jabs, there are numerous interesting anecdotal reports from parents of children who have been trying leucovorin in the past year or so:

https://www.reddit.com/r/Autism_Parenting/search/?q=leucovor...

My hope is that this does lead to breakthroughs in understanding the mechanism for some types of autism, and perhaps even a "miracle" drug akin to how stimulants can radically transform the brains of many with ADHD.

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You can have anecdotal about anything in any direction. Not a great way to come to a scientific conclusion.

Can you also have clinical trials performed under the Biden administration that "significantly improve communication with medium-to-large effect sizes and have a positive effect on core ASD symptoms and associated behaviors" about anything in any direction?

https://pubmed.ncbi.nlm.nih.gov/34834493/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7477301/

I'm not sure how that's related. Some research is flawed and statistics provide misleading or incorrect data so we just... don't care about data?

I am pointing out that your claim that this is just anecdotal is incorrect. There is published research showing medium-to-large effect sizes for exactly this treatment. Why do you think people were trying it on Reddit in the first place?

I agree, but that's a bit of a strawman. I didn't claim it's just anecdotal, I'm saying anecdotes from some reddit posts aren't useful in getting to the truth.

Oh, fair enough.

>For the non-partisans who actually care more about autism in children than they do throwing ideological jabs

It's interesting how USA politics has polarized the autism community so heavily.

Leucovorin only helps in 1 of 6 ways the prenatal damage occurs.Sucks as well that it's prescription.

L-Methylfolate might work as well, as a supplement alternative? Havent tried it. Same with NAC, havent tried it.

CBD will help, no thc allowed, no alcohol allowed.

Omega 3 fish oils will help.

Hot showers will help.

Whole foods, low carbs will help.

You can find Facebook groups filled with thousands of parents who report success with literally any wacky "treatment" you can think of, from chiropractic cures to cancer to making their children drink bleach to "cleanse parasites".

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