I ran irssi for years. I agree... Maybe being paranoid about security?
I personally use weechat inside nsjail on a raspberry pi (isolated rpi is enough here, but just for fun): https://github.com/google/nsjail/tree/master/configs
What's the difference?
A good book on this was "Hacking: The Art of Exploitation".
My argument though is that irssi is that old, I think automatic file receiving (DCC) is off by default and it has sensible defaults and a long history of being reliable(?)