I ran into some deficiencies, though, at least with the parser I was using with Node/TS -- IIRC (and it's been a few years), I wasn't able to specify a wide variety of disparate responses (e.g., an HTTP 200 with an application/json Content-Type header, an HTTP 200 with a text/plain Content-Type header, and an HTTP 400 response with an X-Error-Code header). Since API Blueprint was introduced, the tooling around OpenAPI has improved dramatically and it's become a de facto standard, so I'd probably avoid API Blueprint for anything serious.
It's unfortunate, though, because I really liked the idea.