The author's Go library, sqlitebp, automates these settings and others (NORMAL synchronous, private cache, tuned page cache, connection pool limits, automatic PRAGMA optimize, and in-memory temp storage) to make high-concurrency, reliable usage safer and easier right out of the box
> In serialized mode, API calls to affect or use any SQLite database connection or any object derived from such a database connection can be made safely from multiple threads.
https://www.sqlite.org/threadsafe.html
Many libraries get this wrong and make it unsafe to use from multiple threads despite the underlying provider being capable. I think these are effectively bugs that should be resolved.
In my C# applications, I use System.Data.SQLite and share a single SQLiteConnection instance across the entire app. This connection instance typically gets injected as the first service, so I can just take a param on it any time I need to talk to SQL. Absolutely no synchronization occurs in my code. I've tried Microsoft.Data.Sqlite but it seems to have rare problems with sharing connections between threads.
So your point (which is not very clear to me, with my limited knowledge of C# and SDS) is largely moot in Go terms.