For those with vanity URLs and GMail - the trick I use to manage unsubscribes better is to enable 'catch-all address' and registering for new accounts by their URL and TLD, e.g. news_ycombinator_com@URL.com, or kennethcole_com@URL.com, etc.
Two benefits - 1) easier to remember my login per site and 2) if I start getting spammed as a result of my info being shared with third-parties, I can attribute the original offender to the e-mail address.