nHA is prohibitively expensive to produce and the most effective process that produces the smallest particles is patent-protected by Sangi, and therefore many nHA toothpaste brands only contain a fraction of the concentration used to produce the effective results reported in academic studies (1-2% instead of 10%).

If keratin toothpastes can be produced more economically they could be a better option for mass adoption. For anyone who wants to try nHA toothpaste for remineralization, I can only recommend Sangi Apagard Royal toothpaste ($$$) but it does work quite well when used as directed.