That said, there are two options if the OP _really_ wanted to use Pylons in Common Lisp.
One could attempt to run Pylons under cl-python[1], which is "a fairly complete implementation of Python written in Common Lisp". Cl-python is currently Allegro-only, and likely will not run Pylons without modification.
Alternately, there is Python-on-lisp, which is a FFI to an embedded python interpreter AFAICT. While it will likely be trivial to get Pylons running this way, the interface between the languages seems very low-level, and there does not seem to be any source translation from a sexp syntax to python.
I don't think either way is a good option honestly. If the OP wanted a python framework, they probably would have asked for one, and you could hold your head high rather than ducking ;).