[0]I have a strong suspicion that web.py was influenced by TBNL.
Most of the sbcl hackers hang out in #lisp on irc.freenode.net, so the level of help available around the clock is amazing. There have been a couple times when we were pulling our hair out, got into the #lisp channel, and had a solution in a matter of minutes. Highly recommended, and a very smart group of people.
That said, the learning curve is steep and there is no documentation beyond the examples + source code.
This thread on c.l.l. discusses most of them: http://groups.google.com/group/comp.lang.lisp/browse_thread/...
http://www.defmacro.org/ramblings/weblocks-demo.html
It sounds promising.
It's already very nice (using Lisp turned out to be really great) but some fairly commonly requested features are not yet in. Give it a try, send some questions to the support group, and see if it's right for you.
Yesterday i've wrote simple app, just for fun http://nablaone.net/dino-demo/. What can I say, lisp rulez :-).
REPL -> instant gratification -> flow -> happiness :-)
<ducking>
That said, there are two options if the OP _really_ wanted to use Pylons in Common Lisp.
One could attempt to run Pylons under cl-python[1], which is "a fairly complete implementation of Python written in Common Lisp". Cl-python is currently Allegro-only, and likely will not run Pylons without modification.
Alternately, there is Python-on-lisp, which is a FFI to an embedded python interpreter AFAICT. While it will likely be trivial to get Pylons running this way, the interface between the languages seems very low-level, and there does not seem to be any source translation from a sexp syntax to python.
I don't think either way is a good option honestly. If the OP wanted a python framework, they probably would have asked for one, and you could hold your head high rather than ducking ;).