Real time scientific, physics, and engineering data acquisition and processing applications? Goodness no.
Certainly nothing that might want to generate a waypoint heading update via a division of elapsed time. Not with those random UTC leap seconds that can go either way (although, until now, they've all fallen in one direction).
There's a reason serious real time real world data processing goes with epoch based time, lapsed time since <mark>, it has the nice feature of being monotonically increasing.