Starting a new project, I went with Deno after some research. The NPM ecosystem looked like a mess; and if Node's creator considers Deno the future and says it addresses design mistakes in Node, I saw no reason to doubt him.
We once reported an issue and it got fixed really quickly. But then we had troubles connecting via TLS (mysql on google cloud platform) and after a long time debugging found out the issue is actually not in deno, but in RustTLS, which is used by deno. Even a known issue in RustTLS - still hard to find out if you don't already know what you are searching for.
It was then quicker to switch to nodejs with a TS runner.