I also think this is true related to food. Your body adjusts its metabolism based on the amount of food you eat as long as it's not chronic. That's why you can have competitive eaters that can eat a weeks worth of food and not be overweight. Spikiness and variability are probably good for you. Its funny that the Bryan Johnson types who closely control every calorie in their body have such a bad reaction to any variability. I don't know if its him, but I heard someone not be able to sleep and their levels got all messed up from one sweet. And their conclusion was sweets are so bad for you, rather than you're building your body to be too fragile to shocks.
The interesting thing is when this breaks down. Obviously if you eat a weeks worth of food every day for a sustained period of time, you will start to gain weight. Or if you run 12 miles every day, you will be in such a deficit that it won't be possible to lower your metabolism enough. Outside of the extremes, I think it's a cliff, where you have to have some kind of shock for some period of time for your body to react.