Can't find the post on Reddit right now, but someone broke all three down and it is more nuanced. They act slightly differently in different areas.

Before I started experiments on "my lab rat" with retatrutide, I found that combination of the about half max dose of semaglutide and 1/3 of Max dose of tirzepatide had the best combination of losing weight and lowering side effects. But another "lab rat" did not respond that well to this combo and we keep adjusting it.

Retatrutide so far looks the most compatible, but it is sample of 1.