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Comment by glp1guide | Hacker News Reader

> For semaglutide, the newest and most potent GLP1.

Tirzepatide is the most potent GLP1

https://glp1.guide/content/semaglutide-vs-tirzepatide-clinic...

Can't find the post on Reddit right now, but someone broke all three down and it is more nuanced. They act slightly differently in different areas.

Before I started experiments on "my lab rat" with retatrutide, I found that combination of the about half max dose of semaglutide and 1/3 of Max dose of tirzepatide had the best combination of losing weight and lowering side effects. But another "lab rat" did not respond that well to this combo and we keep adjusting it.

Retatrutide so far looks the most compatible, but it is sample of 1.

Retatrutide looks to be very effective, but it's not possible to get legally/safely at this point. TONS of experience/knowledge in the r/retatrutide subreddit though, a lot of pretty conscientious consumers in there that have done their research, but obviously impossible to recommend outside of finding a sanctioned study to join.

That said, Reta is a triple agonist[0] and it seems to be quite amazing with good muscle retention as well -- it's unclear if this is just the people who are taking it being more likely to be gym goers. Up until now the only formulation I've seen that specifically targets preserving muscle is GLP1s in combination with bimagrumab[1].

[0]: https://glp1.guide/content/a-new-glp1-retatrutide/

[1]: https://glp1.guide/content/preserving-muscle-glp1s-with-bima...

I've had pretty good results on Tirz, definitely interested in how Reta will compare.

This is where I failed as a psychologist because I don't have extensive training in pharmacodynamics, so I forgot that "potent" is a specific term in that world. What I meant was: I subjectively believe that Semaglutide is the best choice for weight loss, given the overall profile and response in my subjective clinical experience.

A fancy way of saying: I *think* Semaglutide is best.

Ah -- the linked research trial contains evidence that it is not the best, Tirzepatide is more effective.

Unless you mean that Semaglutide worked best for you, right now the research points at Tirzepatide being most effective for weight loss (says nothing about t2d though).

No, for my patients. Again. Purely subjective and anecdotal.

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