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Comment by glp1guide | Hacker News Reader

Liraglutide is now available as a generic, but it is the least effective of the big 3 (Semaglutide, Tirzepatide, Liraglutide):

Basically, Tirz > Sema > Lira

https://glp1.guide/content/semaglutide-vs-tirzepatide-clinic...

https://glp1.guide/content/semaglutide-liraglutide-continue-...

https://glp1.guide/content/another-generic-liraglutide-launc...

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Liraglutide isn't fully comparable. On aspect that's a lot touch for many is it's a daily injection. More needles is a turn off for some that can manage 1x/week.

Daily needles vs 12K a year is a tradeoff many people may consider. Especially if insurance companies mandate Liraglutide as a first line treatment.

It’s one people need to consider, but it’s one that the people needing it the most won’t do.

It’s a massive problem for several of my friends who are doctors. Patients start on something that works incredibly well for them then their insurance pushes them to Litaglutide and they loose all of their progress.

Some of it comes down to a fear of needles, some of it comes down to non-compliance, some of it comes down to access.

Daily injections are fatiguing on people. Its a big challenge with diabetes management.

I used to be prescribed Victoza (for diabetes). When liraglutide (the generic) went off-patent, every pharmacy reported that both Victoza and liraglutide were "no longer available".

The generic manufacturers get paid not to make it.

https://www.theatlantic.com/ideas/archive/2023/06/pharmaceut...

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