As an experiment, I tried clicking on a random position after clicking the starting point. And it is possible to that the position is safe. So I don't think the map in no guessing mode is dynamic.
Also in the help section: "In this mode, a starting position is provided, and you never need to guess to complete the board."
Are they all valid, and do they prove that the location you're clicking on is empty? Then you're not guessing.
Are they invalid, or do they not prove that the location is empty? Then you're making a guess that should fail.
Are they valid, comprehensive (there are no more bombs you could mark), and prove that all you have left are random choices? Then clicking is you indicating that you've found all there is to find for now, not a "guess".
Anyway, with the no guessing mode i get more consistent times, and it's more fun/less frustrating. But I get faster times without it, just far more variance.