Gödel's theorem shows that you need an infinite number of axioms to describe reality (given that available reality isn't finite), so any existing axiomatic system isn't enough.
If you’re talking about every true sentence in the language of PA, then not all such sentences are derivable via the theory of PA. If you are talking about the theorems of PA, then these are missing an infinite number of true statements in the language of PA.
Harvey Friedman’s “grand conjecture” is that virtually every theorem that working mathematicians actually publish can already be proved in Elementary Function Arithmetic (much weaker than PA in fact). So the majority of mathematicians are not pushing the boundaries of the existing foundational theories of mathematics, although there is certainly plenty of activity regardless.