The Amyloid hypothesis is not disproven, it is still ONE of the primary candidates for AD.
The problem with any Alzheimer's research is that the disease is still not well understood. It is likely that multiple diseases are being bundled in as a single disease. The tests for AD, are somewhat rudimentary. Beginning with psychological and neurological tests, the blood work to rule out other conditions, followed by a PET scan to look for brain atrophy, and CSF measures for amyloid and tau levels.
It seems almost like they're basically ruling out any disease we can actually measure for and then if it isn't one of those, it's AD.
Does this mean the Amyloid hypothesis is wrong? Unlikely. Is it incomplete? Absolutely!
But articles shouting that all the research should be thrown out are not helpful .
The AD community know that they don't understand the disease, and though therapeutics have been mostly focused on amyloid and tau, research into how the disease works continues.