Basically it would be like flying through explosive sandpaper. Each dust particle would be reduced to plasma, which creates problems of its own.
If you're accelerating there's also the Unruh Effect, which will raise the perceived temperature. By a lot.
There's no way to make this work with any kind of engineering we know about today.
In any case it's probably a moot concern as long as we are living under the twin tyrannies of Newtons Third Law and the Rocket Equation. Building a rocket that can accelerate constantly and noticeably for weeks, months, or even years on end in order to accelerate up to a velocity where Relativity starts to matter requires an absurdly large rocket. Like converting the mass of Jupiter into rocket fuel to make it to the next habitable solar system in a couple of centuries level of craziness.
"Extremely" and "very" don't cut it here. This is beyond the human ability to guess. You'd actually do at least some back-of-the-napkin math to give a real answer, and with a far enough trip, the answer may well become "Almost 100%".