Consumer formats aggravate the audiophile alchemists regularly. Looking through chat from a few decades ago about CD's versus vinyl, adjectives like 'hard' and 'brittle' crop up a lot. The solution technically, was of course to add more distortion, in the form of dithering, to provide an early form of psycho acoustic modelling.
Being a musician as well, I've taken a couple of online 'dare you to tell the difference' tests as well, while researching DAC's for mixing, but not under uncontrolled conditions. I put the top end through custom ribbons comprised of 4Kg of magnet focused on 0.001g of ribbon ( a crude description, but good enough ), and it's an observable difference.
Sitting outside listening to noisy wildlife of all types in the woods, I'm sure 100% of listeners could tell the difference between that aural landscape and any recording, including an MP3.