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AFAICT there exists no conclusive biomedical evidence of permanent physiological effects of LSD. This may mean we're just not looking hard enough, but there's no certainty.

For psilocybin, there is plenty, e.g.: https://pmc.ncbi.nlm.nih.gov/articles/PMC8376772/

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First, you’re cutting an in vitro study. Second, “permanent” is a serious claim that bears a large burden of proof.

I think defining “permanent” would first be useful. The brain is extremely plastic.

Beyond that, OP comment was referring to psychosis effects. See his comment below.

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