I've heard this argument before and I find it insulting, as though it's somehow a moral wrongdoing to prefer children without birth defects. If I could spare my future children from MS, schizophrenia, Downs, Huntington's, Alzheimer's, etc., I'd do it in a heartbeat. Framed differently, who would deliberately inflict a healthy newborn with any of those congenital disorders? That they might live a fulfilling life in spite of their disorder wouldn't make it any less cruel.