It might not be a highly visible downside, but it's there nonetheless. It's better to be honest about that than pretend there is no cultural tradeoff that comes with making such a (IMO) terrible design decision in a language.
There are plenty of people that feel the same way about sigils (like `$foo` in Perl) and semi-colons. I've never understood it -- and likely never will, at this point -- but I don't pretend that there isn't a real demographic effect that these choices bring with them.
Biggest downside: copying and pasting code breaks in a lot of apps.
Jira, Teams, and probably some others, eat whitespace for breakfast. So if a coworker gives me a code snippet they have to manually edit it (often not even possible) OR I have to, or it won't even run. And since the whitespace is significant, it can't be auto formatted.
Whereas with C# you can copy the most fucked up snippet, put it in your editor and boom - auto-formatted and compiles.
Python’s grammar works great for expressions-inside-statements (and expressions-inside-expressions), but it can’t do statements-inside-expressions. Every attempt to support the latter turns out really ugly, at least in corner cases.
That said, I totally agree that full anonymous functions would be useful (especially for more complex logic). Might explore adding those later, but I love the message the current model sends.