The answer is obvious in the programming language case: for those who do not want async, the addition of async/await begins to poison the ecosystem. Now they have a growing list of libraries that they cannot use if they want to avoid async, so the effort involved in picking a library goes up and the odds get increasingly high that they're locked out of some of the key tools in the ecosystem because new libraries without async become harder and harder to find.
For those who really hate colored functions, the addition of async is the removal of a feature: colorless functions are replaced with colored functions.
The same can be said of NPM compatibility. Sure, I can try to avoid it and stick to Deno imports and inspect each library that I use for NPM dependencies. But it gets harder and harder as time goes on, because a key feature of Deno has been removed: it's no longer an ecosystem reset.