So, if you don't have a secondary GPU, you'll need to live without graphics acceleration in the VM... so for a lot of people the "oh you just need to use a VM!" solution is not feasible, because most of the software that people want to use that does not run under WINE do require graphics acceleration.
I tried running Photoshop under a VM, but the performance of the QEMU QXL driver is bad, and VirGL does not support Windows guests yet.
VMWare and VirtualBox do have better graphics drivers that do support Windows. I tried using VMWare and the performance was "ok", but still not near the performance of Photoshop on "bare metal".