While permanent changes to a brain are a thing, I don't think being addicted to smoking means you are addicted to drinking so I don't follow the "logic." You're stating that nicotine is not addictive unless you were previously addicted to nicotine in the presence of MAOIs, in which case nicotine on its own
is addictive now?
I fail to understand how nicotine on its own would satisfy an addictive craving created by a different chemical or combination of chemicals, if it isn't addictive itself.
I'm afraid I don't understand what you mean about a previously emphasized counterexample either. Could you elaborate?