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Comment by pmarreck | Hacker News Reader

My 2 cents-

I lost 50 lbs or so on Mounjaro by the time I reached the maximum dosage. Then, a confluence of supply-chain issues and coverage issues eliminated ALL of it, and within a few short months I had regained all the weight. I finally got coverage again, and supply again (via Zepbound) and began slowly increasing my dosage again.

I'm now at the maximum dose and I've lost exactly 0 pounds from the peak.

So, a warning: Use of this drug seems to be a one-and-done. If you can't keep the weight down after you bottom out and after they take you off the drug, it MAY NOT work again.

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Were you on a program that focused on diet/exercise changes? Did any of those habit changes stick?

The new program does, but hell man, a toddler who doesn't sleep through the night (ever... No family help, either) and who demands 100% attention when he's not at daycare is a massive, massive hit to your free time/motivation/energy/stress. He's wonderful but I'm absolutely fucking miserable right now.

Echoing others here: Yeah, don't be hard on yourself right now. When they get a bit older, you'll get healthier again. It's okay to slide back. The phrase 'relapse is part of recovery' comes to mind. Just focus on the kiddo for now, and you'll get time and energy back sooner than later. This happened to me too, and I managed to get back to a healthier body when we got done with teething. It's different for every kid, but you'll get there, don't worry.

Stay strong and keep going. When they start kindergarten you'll have more time for yourself and things will get better, I promise.

Take my voice for support too. I don’t have kids but see others dads and moms as heroes.

I’ll add that kindergarden age is also around first bicycle age. When I see a parent running with to his cycling kids, the heroes evolve to superhero.

Getting out of school at 2:30 instead of daycare at 5pm says otherwise (my current stressor....).

Similar situation here and my conclusion is that getting in shape requires:

-exercise

-regular sleep

-good diet

With an infant and a toddler on board I can maybe do two, but typically one.

If it's any consolation sleep deprivation prevents long-term memories from being formed, so you won't remember most of this.

In the first three months after my first child was born there was definitely something happening, but I wouldn't know - I don't recall any of it.

I've got two toddlers and still manage to get outside for a run everyday. Used the Bob stroller when they were younger, now they ride bikes and I jog with them. When my son wouldn't sleep through the night for his first year (pre-walking), I'd set him in a play pen and run on the treadmill nearby.

Hang in there! And focus on the fun times. I'm assuming you're already tried many things, but if you haven't talked to your pediatrician, he might be able to help. Melatonin helped one of our foster kids fall asleep, but yeah, it didn't help him sleep all the way through the night. Good luck!

Of all the information I've seen about Semaglutides the only people I've seen it keep the weight off are:

1. High end personal trainers clients, for which semaglutide was used in conjunction with the trainer's workout regiment and diet.

2. Body builders and models, for which semaglutides simply replaced caffine/adderall/ephedrine.

The drugs can't induce the lifestyle change needed to keep the weight off (nor will it give you the motivation to go to the gym and build muscle). I'm thinking for now, it's a race to see how cheap these drugs can get and ensuring they have no side effects from very long term use. Overall I think the drugs are a net good and I'm interested for seeing the effects for myself, but I'm in good shape and $500/mo is still steep.

Have to say I basically take the opposite on everything you say here. I know quite a few people who aren't super active (myself included) who took it and went off and kept the weight off.

And they actually do induce lifestyle changes, which is the fascinating part. Not for everyone, but the impulse control changes are dramatic. I had a friend credit him going to therapy for the first time in his life and reading for the first time since high school to it which was crazy, but makes sense because it also helped him quit smoking weed so he had a lot more time.

Do you know which drug they took? Do you know if it was a compound? I'm a layman here and I'm interested in the success stories.

Ignoring the weightloss, I find the life quality improvements properties of the drug fascinating and it would be my number 1 reason for trying it.

The best is definitely Tirzepatide, it's both stronger and easier to tolerate. You can find it online from more or less reliable sources.

This seems to starkly contradict the current data on glp-1 agonists.

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