The recently released sqlite_rsync utility uses a version of the rsync algorithm optimized to work on the internal structure of a SQLite database. It compares the internal data pages efficiently, then only syncs changed or missing pages.
Nice tricks in the article, but you can more easily use the builtin utility now :)
I blogged about how it works in detail here: https://nochlin.com/blog/how-the-new-sqlite3_rsync-utility-w...