There's literally no machine on Earth today that can deal with that (as a single file, I mean).
Oh? Certainly not in RAM, but 4 PiB is about 125x 36TiB drives (or 188x 24TiB drives). (You can go bigger if you want to shell out tens of thousands per 100TB SSD, at which point you "only" need 45 of those drives.)
These are numbers such that a purpose-built server with enough SAS expanders could easily fit that within a single rack, for less than $100k (based on the list price of an Exos X24 before even considering any bulk discounts).
42.zip has five layers. But you can make a zip file that has an infinite number of layers. See https://research.swtch.com/zip or https://alf.nu/ZipQuine