Extreme ELI5 TL;DR: Your Python programs using the cpython interpreter and its built in cryptographic modules will now be using safer and faster, with no need for you to do anything.
Also, pyca/cryptography uses OpenSSL. OpenSSL is fine, but has the same "problem" as the previous python stdlib implementation. (Personally I think it's an acceptable risk. If anything, swapping in 15,000 lines of new code is the greater risk, even if it's "verified")
bear in mind that performance is tricky -- see my comment about NEON https://github.com/python/cpython/pull/119316#issuecomment-2...
(You could also make the argument that if previous implementations that were replaced were insecure that their relative performance is ultimately irrelevant, but I'm ignoring that since it hinges on a known unknown.)