Ref. manufacturing, any serious-scale company is not going to commit to a decade-long (or more) plan to building factories in the US with this sort of uncertainty; I'm sure a few will pay lip-service to the current POTUS but what CEO is going to commit to the long-term in a country in turmoil?
And even when this is past, those same CEO's - and their successors - will think long and hard about committing to any long-term investment in the US.