Nit: while I fully support making the web more efficient and hope that Nue is successful in promoting that, I'm skeptical of the "crashing" JS claim here. You can do amazingly efficient things with TypedArrays, the forgotten middle child between JavaScript and WASM.
Having said that, this requires building a few clever data structures on top (I've gotten a lot of mileage out of "typed" dequeues, and (sparse) bitmaps myself), often emulating structs in a language unable to express them properly. So the resulting code is not exactly idiomatic JavaScript — which I presume is what they implied here. Plus in this case it probably still wouldn't be as fast as a well-written WASM implementation, since almost all of the work is likely spent searching with only a little bit of DOM manipulation at the end.
So I'm both agreeing and feeling like it slightly overgeneralizes. I guess my point is: yes, let's be critical of bloated web frameworks, but let's not equate React with JavaScript either.