The biggest issue will be cultural. Don't be a workaholic. Don't live to work. Don't bring that culture here. It is fine if you like to work, but don't project that as expectations on others.
Source: I'm US person who moved to Europe. I've worked for US companies as well as global and European companies.
Will compensation be geared towards it? Or am I expecting to make like $70000 while working 60 hours per week?
The reason you see people talking about terrible work hours is that when you are inexperienced you will definitely be working far more than 40 hours because you will not be able to hit your deadlines otherwise. Getting promoted within a company often requires worked extra hours, however working extra hours is not necessary for good reviews in a healthy company.
If you are a SWE and work for a tech company, you will find that taking European amounts of vacation is okay, again as long as you hit your deadlines. No one has ever cared that I take 6 weeks a year in vacation. But I also make sure to give plenty of notice on my vacations so the company can plan around my absence and I am generally considered to be a productive employee. I have never been laid off from a company. In fact I have survived 2 lay offs.
While US work culture is bad (I will self admit that I do like to work and sometimes work because I want to.), it is not as horrific as people like to claim as long as you advocate for yourself and ask the right questions in interviews to make sure that the team you will be placed on doesn't have ridiculous standards for performance.
I have experience in the IT sector as a manager and while many openly say that the expectations are 40 hours a week wink wink but be expected to answer the phone 24/7 whenever we need you. Oh, 60 hours already this week? Too bad.
Taking time off? Oh, if you even have time. In the companies I have worked, taking 10 days off a year was considered a perk.