(OP Here)

I think it is important to note that there is a big difference between weeding out resumes due to a heuristic like experience, and weeding out candidates based on experience.

Take the oft-quoted Tristan Walker/Foursquare example. If Tristan had simply sent his resume to "jobs@foursquare.com", It's likely that Dennis and Naveen would have hardly looked past the first lines of his resume. However, because Tristan worked his ass off to reach out directly, he was given a chance to do amazing things despite his inexperience.

I entirely agree that inexperienced people shouldn't be discouraged from trying to punch above their weight. I just believe that the bar for them to gain entry is a bit higher than submitting a resume.