If you want to throw together some quick thing or toy project or whatever sure, knock yourself out. But I'll honestly never respect people who write large "serious" applications using Python or JS for their backend. There are lots of great languages you can use for a backend. Java, C#, Go, lots of stuff. Js and python are the kind of languages you choose when you either don't know any other language or you don't know that they're ass.
The only good excuse to use JS is that your code needs to run in a browser. The only good excuse to use python is that you're just making a tiny little toy thing. Or you're doing data science stuff/ML, in any case you're not creating a large complex application. And you certainly don't care much about performance.
People invest so much time and money into creating more JS libraries and frameworks and stuff when what we should really be investing time and money into is creating an actually good language for the web. JS is the epitome of sunk cost fallacy.
"But TS" no. TS is just JS with a bunch of overly complicated type bullshit you have to deal with. It is a better dev experience than JS so I do use it, but it's less a cure and more a band aid over the huge, gaping and pus-dripping wound that is JS.