Lisp machines belong to a past so distant I don't think their are relevant for exploring the possibilities of contemporary hardware. The design constraints moved - clock is in the gigahertz range, memory is orders of magnitude slower and we have to deal with multiple levels of cache between them. And that's just the start.
In fact, the concept of "doing it in hardware" (be it specialized logic or dedicated generic processors) is alive and well (and bearing fruit) on every mainframe manufactured.
The fact we all use similar x86 boxes designed to be compatible with MS-DOS is a tragedy.