It would be possible that MS wrote a TypeScript compiler that emits native binaries and that made the language 10x faster, why not?
Transpiling in itself also doesn't remove the possibility of producing more optimized code, especially if the source has more information about the types. The official TypeScript compiler doesn't really do any of that right now (e.g. it won't remove a branch about how to handle a variable if its type equals a number even if it has the type information to know it can't have been set to one). Heck, it doesn't even (natively, you can always bolt this on yourself) support producing minified transpiled code to improve runtime parsing! In both examples it's not because transpilation prevents optimization though, it's just not done (or possibly worthwhile if TS only ever targets JS runtimes as JS JIT is extraordinarily good these days).