My biggest DNS lag was before I used PiHole and was relying on my router, which upstream to 8.8.8.8. I've just assumed that little thing was overloaded or that Comcast was just having a "hiccup".
EDIT: I do not know why its an issue with firefox and not chrome, it's likely QUIC fucking up since it cant fragment and needs to fall back to TCP, chrome is probably error handling this better... dropping the MTU that low will make the fallback explicit: https://blog.apnic.net/2019/03/04/a-quick-look-at-quic/
EDIT2: Could also try disabling QUIC, instructions here: https://developers.cloudflare.com/cloudflare-one/policies/ga...
Whenever someone says how fast Chrome is I think about this.