I think business relationship is not that dissimilar to other relationships. I think you should voice your concerns, while still letting the manager know that you are open to disagree and still commit. Only when your disagreement becomes too strong, then you leave.
If you have concerns and constructive feedback, I found most managers to have agreeable reactions to it.
Maybe I was just lucky, but I did have this experience across four companies. What you should not do is bare criticism without constructive feedback. Most managers will respond positively, even if nothing happens in the end. And after voicing it for several times, you can feel better for leaving, because you also did what you could from your end.