Upgraded one machine from Snow Leopard (10.6) and another from Lion (10.7). No issues what so ever. Both still work perfectly, all my stuff from HomeBrew transferred over without any issues either (which is fantastic, did not want to have to recompile all of that stuff).
The upgrade was fast and easy, definitely not something I expected and I had backed up my machine to do an install from scratch, but not required at all.